A REVIEW ON IMPORTANCE OF NS1 OF DENGUE VIRUS

Abstract

The non-structural 1 (NS1) dengue virus (DENV) protein plays an important role in the replication of viral RNA and has a key location in the pathogenesis of DENV. DENV NS1 is a glycoprotein expressed as soluble monomers in compromised mammalian cells that dimerize in the lumen of the endoplasmic reticulum; NS1 is then transferred as a hexameric complex to the cell surface where it persists aligned with the membrane or is secreted into the extracellular environment. The DENV NS1 protein has also been intensively studied as a possible candidate for vaccines and antiviral drugs over the last three decades. Moreover, the main diagnostic marker for dengue infection is NS1. This analysis highlights several critical topics relating to the role of NS1 in the pathogenesis of DENV and its biotechnological applications, both as a target for the production of effective and safe vaccinations and antiviral medicines and as an instrument for the production of precise diagnostic methods.