A REVIEWPAPER ON NANOTECHNOLOGY BASED METHODS FOR IMPROVING ORAL BIOAVAILABILITY

Abstract

Oral administration, since it provides high patient enforcement, is the most convenient path between different drug distribution paths. However, in effective oral drug delivery, low aqueous solubility and poor enzymatic/metabolic stability of drugs are major constraints. There are many approaches to improving the hydrophobic drug issue. Among the different methods, the drug delivery method focused on nanotechnology has the potential to solve the problems associated with the oral route of administration.In many areas of medicine, there are innovative drug delivery systems available. In the management of hypertension, the use of these devices continues to broaden. In order to enhance the solubility profile, dissolution, and consequently the bioavailability of hydrophobic antihypertensive drugs, the present review focuses on the different nano carriers available in oral drug administration. The most popular, simple, and widely used route of administration is oral drug delivery as it offers benefits such as painless administration, no aid, and patient compliance compared to other routes such as intramuscular, intravenous, and pulmonary.