TOXIC EFFECTS OF C60 FULLERENE NANOPARTICLES: A REVIEW PAPER

Abstract

While several new reports have portrayed the toxicity of water-soluble C60 fullerene nanoparticles, none have detailed the toxicity coming about because of the inhalation openings to C60 fullerene nanoparticles or microparticles. To address this information hole, we presented male rodents to C60 fullerene nanoparticles (2.22 mg/m3,55 nm width) and microparticles (2.35 mg/m3, 0.93 mm distance across) for 3 h daily, for 10 back to back days utilizing a nose-just openness framework. Nanoparticles were made using an aerosol vaporization and buildup measure. Nanoparticles and microparticles were exposed to high-pressure liquid chromatography (HPLC), XRD, and scanning laser Raman spectroscopy which in total demonstrated no substance change of the C60 fullerenes happened during the aerosol generation. At necropsy, no gross or minuscule sores were seen in one or the other gathering of C60 fullerene openings rodents. Hematology and serum science results discovered genuinely critical contrasts, albeit little in extent, in both openness gatherings. Examinations of bronchoalveolar (BAL) lavage liquid boundaries distinguished a huge expansion in protein fixation in rodents presented to C60 fullerene nanoparticles. BAL liquid macrophages from both openness bunch contained earthy colored shades, steady with C60 fullerenes. C60 lung molecule troubles were more noteworthy in nanoparticle-uncovered rodents than in microparticle-uncovered rodents. The determined lung affidavit rate and testimony parts were 41 and half more noteworthy, individually, in the C60 fullerene nanoparticle–uncovered gathering than in the C60 fullerene microparticle–uncovered gathering. Lung half-lives for C60 fullerene nanoparticles and microparticles were 26 and 29 days, individually. In rundown, this first in vivo appraisal of the toxicity coming about because of inhalation openings to C60 fullerene nanoparticles and microparticles discovered negligible changes in the toxicological endpoints analyzed. Extra toxicological appraisals including longer term inhalation openings are expected to build up a superior and more definitive understanding of the likely toxicity of breathed in C60 fullerenes whether in nanoparticle or microparticle structure.