A REVIEW PAPER ON DRUG DELIVERY SYSTEMS FOR THE SYNERGISTIC CANCER CURE

Abstract

Cancer remains difficult to treat, despite being a leading cause of death worldwide, due to the emergence of drug resistance and serious adverse effects associated with traditional chemotherapy. Thus, due to the synergistic effects of drugs and suppression of drug resistance, combination chemotherapy is potentially beneficial. A promising method for the successful treatment of different cancers is nanoparticle-mediated chemotherapeutic delivery because it can simultaneously improve therapeutic effects and decrease side effects. In addition, the loading of various chemotherapeutic agents into these systems could enhance antineoplastic efficacy. Recent developments in combination chemotherapy using small-molecule chemotherapy agents by nano-carrier systems such as liposomes, polymeric micelles, dendrimers, polymer-drug conjugates, and mesoporous silica nanoparticles are highlighted in this study. In particular, it highlights the specific properties of these systems that make them ideal for optimized effectiveness and safety treatments and clarifies areas in which existing therapeutic strategies can be improved.