Anti-diabetic evaluationof methanolic extract of Lagerstroemia microcarpa Wight in streptozotocin induced diabetic Wistar albino rat model

Abstract

Object: The object of research paper was to evaluate the ant-diabetic activity of methanolic extract of Lagerstroemia microcarpa Wight in streptozotocin (STZ)-induced diabetic rats.

Material and methods: The methanolic extract of Lagerstroemia microcarpa Wight (MELMW) of different concentration (100 and 200 mg/kg b.w.) was administered orally and evaluated for the estimation of biochemical parameters (SGPT, ALP), skin & behavioral activity, oral glucose tolerance test and VLDL and LDL cholesterol (VLDL-C and LDL-C) and anti-diabetic potential.

Result and Discussion: The anti-diabetic activities data indicates substantially altered physiological and biochemical aspects.  In Lagerstroemia Microcarpawight(MELMW), the dose of 100 and 200 mg/kg.shown the cholesterol level 138.0 mg/dl and 125.0 mg/dl as compared to standard drug Glibenclamide which shown the cholesterol level 110.0 mg/dl at a dose of 500 mg/kg.Study result indicates that significant decrease in total cholesterol, triglyceride and LDL cholesterol levels was observed after treating the STZ induced diabetic rats with100 and 200 mg/kg body weight leading to a significant increase in the cholesterol levels.

Conclusion: In acute toxicity study no toxic symptoms were observed for MELMW, up to dose 3000 mg/kg. The MELMW possess hypoglycemic activity, which varies with concentration. In neutral and basic media, the hypoglycemic activity was considerably more than that in acidic media. This study demonstrates the anti-diabetic potential of Lagerstroemia microcarpa wight and offers scientific validation and basis to develop anti-diabetic drug.