Formulation development and evaluation of amiodarone hydrochloride co-crystal tablet for bioavailability enhancement

Abstract

Amiodarone HCl is an anti-arrhythmic drug. This medication is used to treat certain types of serious
(possibly fatal) irregular heartbeat (such as persistent ventricular fibrillation/tachycardia). It is used
to restore normal heart rhythm and maintain a regular, steady heartbeat. Co crystals is an
alternative approach based on crystal engineering to enhance specific physicochemical and
biopharmaceutical properties of active pharmaceutical ingredients (APIs) when the approaches to
salt or polymorph formation do not meet the expected targets. A crystal engineering approach was
used to design, develop a Co crystal of the API. Co crystals are solid substances, which consist of few
components mixed together. Co crystals are multi component systems in which two components, an
active pharmaceutical ingredient and a co former were present in stoichiometric ratio and bonded
together with non-covalent interactions or Hydrogen bonding in the crystal lattice. There are a lot of
ways of co crystals production and application. the objective of the present work was focused on the
improvement of aqueous solubility of drug by formulating Co-crystal of AmiodaroneHCl.