BIOACTIVE COMPOUNDS INVOLVED IN THE ANTIMICROBIAL ACTIVITY OF GANODERMA LUCIDUM (CURT FR) P.KARST

Abstract

Medicinal mushrooms form the backbone of traditional medicine in the last few decades with the intense pharmacological application. In developing countries it is estimated that about 80 of the population depends on traditional medicine for their primary health care. The medicinal mushroom G.lucidum is a species of basidiomycetes The medicinal mushroom as traditional medicine or a folk medicine has  been used for the treatment of various human diseases. The effect of qualitative and quantitative bioactive compounds present inG.lucidumlike alkaloids, anthraquinones, cardiac glycosides, flavonoids, phenol, polysaccharides, protein, reducing sugar, saponins, steroids, tannins and terpenoids were determined.The antimicrobial properties of G.lucidum using various solvent extracts likeaqueous, benzene, ethanol and methanol extracts were carried out against clinical microbes by agar well diffusion method and the zone of inhibition were calculated. The maximum inhibition of Bacillus cereuswas observed in G.lucidumwith ethanol extract and minimum inhibition was observed in Escherichia coli. TheG.lucidumwith ethanol extract has maximum inhibition agains tFusariumsp and minimum inhibition was recorded inPenicilliumsp. respectively