Memory enhancing activity of chloroform extract of leaves of Plumbago zeylanica Linn.

Abstract

AIM- The main aim of our study is to study the memory enhancing activity of leaves of Plumbago
zeylanica Linn. by morris water maze. MATERIAL & METHODS- Leaves was extracted by petroleum
ether and after defatting the leaves the dried mark was extracted by using chloroform. Chloroform
extract in a dose of 200 and 400 mg/kg was evaluated by morris water test and brain acetylcholine
esterase level was measured. RESULT- Chloroform extract showed significant decrease of EL and
increase of TSTQ by mice in Morris water maze indicates improvement of learning and memory. It
also significantly decreases the cholinesterase level in brain. CONCLUSION- Learning and memory
of mice doubtless through embarrassment of brain acetyl cholinesterase activity and through
involvement of GABA-benzodiazepine pathway.