Nuclease , Superoxide Dismutase Activity and DNA Binding of a New Copper Complex

  • Anandveer Singh Sindhu, Vikesh Kumar Singh

Abstract

A tridentate ligand was converted into metalloligand [Cu(pic)2] (pic = picolinate anion) when Pyimpy (Pyimpy = 1-phenyl-1-(pyridin-2-yl)-2-(pyridin-2-ylmethylene) hydrazine) was reacted with Cu(ClO4)26H2O in presence of triethylamine and a facile oxidation of azomethine function to carboxylic acid was observed. The resultant complex [Cu(pic)2] afforded superoxide dismutase (SOD) activity and IC50 value was found to be 2.60 mM in xanthine/xanthine oxidase nitroblue tetrazolium assay. This small molecule exhibited nuclease activity by cleaving pBR322 DNA oxidatively in presence of 2-mercaptoethanol.

Published
2019-12-31
Section
Articles