Pharmacological Evaluation and Comparison studies of Ethanolic extracts of Leaves of Aegle Marmelos and Trigonella Foenum Graecum with standard Drug Glibenclamide on Alloxan-Induced Diabetic Mice
Abstract
In the present study, Ethanolic extracts of Leaves of Aegle marmelos and Seeds of Trigonella foenum graecum were evaluated for thier antihyperglycemic, antihyperlipidemic, and antioxidant effects against normal and alloxan (AXN)-induced diabetic mice. Type II diabetes was induced in Swiss Albino Mice by administration of a single intraperitoneal (IP) injection of AXN at a dose of 150 mg/kg. Effects of three different doses of these extracts (100, 200, and 300 mg/kg/day, I.P.) and Glibenclamide (5 mg/kg/day, ) administered for 28 days were studied on parameters such as blood glucose, lipid profile.. Results were analyzed using Studentst Test. No significant changes were noticed in blood glucose, serum lipid levels, and kidney parameters in normal mice treated with plant extracts. The efficacy of both plants extract as an antihyperglycemic, antihyperlipidemic, and antioxidant agent in AXN-induced diabetes was comparable to that of the standard drug , 5 mg/kg of Glibenclamide. Present findings provides substantial comparision that Plants extracts has significant antihyperglycemic, antihyperlipidemic, and antioxidative effects in diabetic experimental mice. Hence, these extracts i.e. Seeds of Trigonella foenum graecum and Aegle Marmelos may be regarded as a promising natural and safe remedy for the prevention or delay of diabetic complications.