A Study of Formulation and Evaluation of Rectal Drug Delivery System of Atenolol & Diltiazem Hydrochloride

Abstract

Abstract
Administration of drugs in conventional manner is not free from toxicity and G.I. tract related problems. Also hepatic metabolism reduces bioavailability of drug and to initiate and sustained therapeutic action higher doses of drug is needed. Only I/V can solve the above problem, however continuous presence of needle in the circulatory portal is inconvenient to patient. Ultimately patient compliance is reduced, and management of disease suffers. Rectal delivery is an answer and also a safe and convenient alternative to I/V. It obviates hepatic metabolism also, the problems concerned with G.I. tract route are absent. Processing of rectal delivery system is also simple as compared to parental and solid dosage forms.
Keywords: Rectal Drug, Drug Delivery System, Atenolol, Diltiazem Hydrochloride Etc.