Insights into Non-Homologous End Joining (NHEJ) Pathway: An emphasis on ProteinProtein Interactions

  • Sugunakar Vuree et al.

Abstract

The error prone activity of non-homologous end joining (NHEJ) is a part of well-known
DNA repair pathway that leads to de novo generation of mutations, viz. deletions,
insertions, mismatches and translocations. Increased levels of endogenous double
stranded breaks (DSBs) trigger the NHEJ pathway. In view of growing number of
protein-protein interaction studies, whether or not a relationship between the gene
variants of XRCC5, XRCC6, XRCC7 specific to NHEJ pathway could be established
using in silico approaches. In this perspective, we deliberate whether these genes
involved in apoptosis, proliferation and differentiation could be used to decipher the
function of intermediate proteins

Published
2019-12-24
Section
Articles