“Identification of the putative IRE1 and HACA gene of Aspergillus terreus.”

  • SaiketSena et al.

Abstract

Aspergillosis is a pulmonary disease caused by the species of Aspergillus. It mostly targets
the immunocompromised individuals. Among the identified Aspergillus sps. more than 90%
of cases are of Aspergillus fumigatus. However, recently,another filamentous fungi
Aspergillus terreusis reported. It is showing resistant to the existing drugs used for the
therapy. To identify the genes which are involved in the homeostasis pathway called as
unfolded protein response pathway (UPR), we have used the insilico and molecular technique
to identify the IRE1 and HACA gene in A. terreus. Our study suggests the putative IRE1 gene
is 750 bp, and putative HACA is 1.0 Kb. Our results are contrary to the expected size of the
IRE1 gene, as reported in other fungi. We deduce that the IRE1 gene is either truncated or
there is miss primed amplification. Nevertheless, it is a first report to show these genes are
present in this human opportunist pathogen.

Published
2019-12-24
Section
Articles