Synthesis, Characterization and Antimicrobial Activity of 5-hydroxy-2-(5-methylfuran-2-yl)-4H-chromen-4-one

Abstract

There has been increasing in the research on flavonoids from plant sources because of their versatile health benifits reported in various epidemiological studies. Fruits and vegetables are the main dietary sources of flavonoids for human, along with tea and wine. 5-hydroxy-2-(5-methylfuran-2-yl)-4H-chromen-4-one was synthesized by Claisen-Schmidt condensation method from 2,6-dihydroxy acetophenone  and 5-methyl-Furaldehyde to gives chalcone and which on oxidation with DMSO/I2. Spectroscopic characterization using UV-visible, IR, ¹H NMR, Mass spectra, properties and antimicrobial activity has been investigated for 5-hydroxy-2-(5-methylfuran-2-yl)-4H-chromen-4-one.  The IR bands for Carbonyl group (-C=O in pyron ring) for 5-hydroxy-2-(5-methylfuran-2-yl)-4H-chromen-4-one appear at 1606 per cm which agrees with the general range of flavones. The 5-hydroxy-2-(5-methylfuran-2-yl)-4H-chromen-4-one has two UV matching bands at 258 nm and other at 339 nm which lies in the range of flavone. In the mass spectrum of 5-hydroxy-2-(5-methylfuran-2-yl)-4H-chromen-4-one molecular ion peak corresponding to [M⁺] peak is in good agreement with their structure. The flavone shows moderate to good Antibacterial and Antifungal activity.