A PATTERN OF LIPID PROFILE IN THE PATIENTS WITH THYROID DISORDERS – A HOSPITAL BASED STUDY

Abstract

Thyroid gland is one of the important endocrine glands which produces thyroxines and regulates metabolic process of our body. The lipid metabolic pathways and its transport through lipoprotein is regulated by thyroid hormone through the enzymes involved in these pathways. The current study is designed to find the relationship between the thyroid disorders and serum lipids and different lipoproteins. A hospital-based study involving data 377 subjects of age between 20-80, visiting Central Lab of Biochemistry Department in PIMS Hospital, Jalandhar Punjab. Out of 377, eighty-four subjects were considered as overt hypothyroidism, eighty subjects were considered as control subjects and 9 subjects were considered as hyperthyroidism. Among 84 hypothyroid patients, 70.2% were female and 29.76% male and also from 80 control subjects 62.5% were female and 37.5% male. All the lipids except high-density lipoprotein (HDL-C) and thyroid stimulating hormone (TSH) has been increased whereas high-density lipoprotein (HDL-C), free T3 and free T4 were decreased in the case of hypothyroid when compared to control. In both hypothyroid and control subjects, free T3 had non-significant correlation with TC, HDL-C and LDL-C, but association between free T3 and TGs showed negative correlation in hypothyroid subjects and showed non-significant correlation in control subjects. Free T4 had shown a non-significant relationship with all the lipid components in both hypothyroid and control subjects. Hypothyroidism was more prevalent than other thyroid disorders. The mean level of TC, LDL-C, TGs and TSH were higher and HDL-C, FT3 and FT4 were lowered in hypothyroid as compare to control subjects. Statistically significant correlations were reported between different parameters of the study.