Antipsychotic potential and molecular modelling of 1-(4-methoxybenzofuran-5-yl)-3-phenylpropane-1, 3-dione.

Abstract

Psychosis is a chronic disabling psychiatric disorder affecting 1% of the population worldwide. The search for novel pharmacotherapy from medicinal plants for psychiatric illnesses has progressed significantly from the past few decades and their therapeutic potential has been assessed in a variety of animal models. The aim of our study was to screen 1-(methoxybenzofuran-5 yl)-3-phenylpropane-1,3-dione for its antipsychotic potential. Dopamine is a neurotransmitter in brain which has inhibitory effect on schizophrenia. Dopaminergic theory of schizophrenia states that irregularities of dopamine in the mesolimbic area of brain. It provides in depth analysis of antipsychotic effects in laboratory animals. The same is supported by computational work on D2 receptors inhibitory potency at molecular level using docking studies.